United States securities and exchange commission logo February 5, 2021 Yuichi Iwaki, M.D., Ph.D. President and Chief Executive Officer MediciNova, Inc. 4275 Executive Square, Suite 300 La Jolla, CA 92037 Re: MediciNova, Inc. Registration Statement on Form S-3 Filed January 29, 2021 File No. 333-252592 Dear Dr. Iwaki: This is to advise you that we have not reviewed and will not review your registration statement. Please refer to Rules 460 and 461 regarding requests for acceleration. We remind you that the company and its management are responsible for the accuracy and adequacy of their disclosures, notwithstanding any review, comments, action or absence of action by the staff. Please contact Jeffrey Gabor at 202-551-2544 with any questions. Sincerely, Division of Corporation Finance Office of Life Sciences cc: Jordan F. Murray, Esq.