United States securities and exchange commission logo

                          August 31, 2022

       Yuichi Iwaki, M.D., Ph.D.
       President and Chief Executive Officer
       MediciNova, Inc.
       4275 Executive Square, Suite 300
       La Jolla, California 92037

                                                        Re: MediciNova, Inc.
Statement on Form S-3
                                                            Filed August 26,
                                                            File No. 333-267094

       Dear Dr. Iwaki:

              This is to advise you that we have not reviewed and will not
review your registration

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

                                                        Please contact Daniel
Crawford at 202-551-7767 with any questions.


                          Division of Corporation Finance

                          Office of Life Sciences
       cc:                                              Kirt Shuldberg, Esq.