

<!-- RRD ActiveDisclosure(SM) XBRL Schema Document - http://www.financial.rrd.com/ -->
<!-- Creation Date      : 2016-07-26T17:43:26.4759755+00:00 -->
<!-- Version            : 2.3.4.12 -->
<!-- Package ID         : E4726CA02DA22DAACCBCD70B94F7DD14-0001226616-001605 -->
<!-- Copyright (c) 2016 R. R. Donnelley & Sons Company. All Rights Reserved. -->
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  <element id="mnov_ClassOfWarrantOrRightExpiredUnexercised" name="ClassOfWarrantOrRightExpiredUnexercised" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <element id="mnov_WarrantsExpirationDate" name="WarrantsExpirationDate" type="xbrli:dateItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <element id="mnov_WarrantOneMember" name="WarrantOneMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="mnov_WarrantTwoMember" name="WarrantTwoMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="mnov_WarrantThreeMember" name="WarrantThreeMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="mnov_PreferredStockConversionRate" name="PreferredStockConversionRate" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <element id="mnov_SeriesBConvertiblePreferredStockMember" name="SeriesBConvertiblePreferredStockMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
</schema>





