Accounting Policies [Abstract] Accounting Policies [Abstract] Accounts Payable Current Accounts payable Accrued Liabilities Current Accrued expenses Accumulated Other Comprehensive Income Loss Net Of Tax Accumulated other comprehensive loss Additional Paid In Capital Additional paid-in capital Adjustments To Reconcile Net Income Loss To Cash Provided By Used In Operating Activities [Abstract] Adjustments to reconcile net loss to net cash provided by (used in) operating activities: Aggregate Intrinsic Value Of Stock Options Exercisable Aggregate Intrinsic Value Of Stock Options Exercisable Intrinsic value Amendment Flag Amendment Flag Antidilutive Securities Excluded From Computation Of Earnings Per Share Amount Total Antidilutive Securities Excluded From Computation Of Earnings Per Share By Antidilutive Securities [Axis] Antidilutive Securities [Axis] Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items] Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] Antidilutive Securities Name [Domain] Antidilutive Securities, Name [Domain] Aspire Capital Fund Llc [Member] Aspire Capital Fund Llc [Member] Aspire Capital Fund Llc Assets Total assets Assets [Abstract] Assets Assets Current Total current assets Assets Current [Abstract] Current assets: Award Type [Axis] Award Type [Axis] Basis Of Accounting Policy Policy [Text Block] Basis of Presentation Basis Of Presentation And Summary Of Significant Accounting Policies [Line Items] Basis Of Presentation And Summary Of Significant Accounting Policies [Line Items] Basis Of Presentation And Summary Of Significant Accounting Policies [Line Items] Basis Of Presentation And Summary Of Significant Accounting Policies [Table] Basis Of Presentation And Summary Of Significant Accounting Policies [Table] Basis Of Presentation And Summary Of Significant Accounting Policies [Table] Cash And Cash Equivalents At Carrying Value Cash and cash equivalents, end of period Cash and cash equivalents, beginning of period Cash and cash equivalents Cash And Cash Equivalents Period Increase Decrease Net increase (decrease) in cash and cash equivalents Cash Equivalents Money Market Funds Cash Equivalents Money Market Funds Cash and cash equivalents, including money market accounts Class Of Stock [Domain] Class of Stock [Domain] Class of Warrant or Right, Exercisable Class Of Warrant Or Right Exercisable Warrant, exercisable shares Class of Warrant or Right, Exercised in Period Class Of Warrant Or Right Exercised In Period Warrant exercised Class Of Warrant Or Right Exercise Price Of Warrants Or Rights Common share exercise price Class of Warrant or Right, Expiration Period Class Of Warrant Or Right Expiration Period Warrant, expiration period Class Of Warrant Or Right Number Of Securities Called By Warrants Or Rights Warrant issued to purchase Common shares Class Of Warrant Or Right Outstanding Warrant, Outstanding Class Of Warrant Or Rights Exercisable Period From Date Of Issuance Class Of Warrant Or Rights Exercisable Period From Date Of Issuance Warrant, exercisable period Common Shares In Underwritten Public Offering Common Shares In Underwritten Public Offering Public Offering Common Stock Capital Shares Reserved For Future Issuance Common Stock reserved for future issuance Common stock fair market value percentage. Common Stock Fair Market Value Percentage Common stock fair market value, percentage Common Stock Issued Under Underwritten Public Offering Price Per Share Common Stock Issued Under Underwritten Public Offering Price Per Share Public Offering per unit Common Stock Maximum Sale Amount Under Purchase Agreement Common Stock Maximum Sale Amount Under Purchase Agreement Stock Purchase Agreement, maximum amount of sale Common Stock [Member] Common Stock Common Stock Par Or Stated Value Per Share Common stock, par value Common Stock Shares Authorized Common stock, shares authorized Common Stock Shares Issued Common stock, shares issued Common Stock Shares Outstanding Common stock, shares outstanding Common Stock Shares Subscriptions Stock purchase agreement, aggregate amount of common stock agreed to be purchased Common Stock Value Common stock, $0.001 par value; 100,000,000 shares authorized at March 31, 2014 and December 31, 2013; 24,088,419 and 22,495,443 shares issued and outstanding at March 31, 2014 and December 31, 2013, respectively Common Stock Warrant [Member] Common Stock Warrant [Member] Common Stock Warrant Comprehensive Income Net Of Tax Comprehensive loss Convertible Preferred Stock [Member] Convertible preferred stock, as converted Convertible Preferred Stock Shares Issued Upon Conversion Series B Preferred Stock, Shares Issued upon Conversion Convertible Preferred Stock Terms Of Conversion Series B Preferred stock conversion term Current Fiscal Year End Date Current Fiscal Year End Date Deferred Rent Non Current Deferred Rent Non Current Long-term deferred rent Deferred Revenue Deferred revenue related to research and development services Deferred Revenue Noncurrent Long-term deferred revenue Deferred Revenue Period Increase Decrease Amortization of Kissei upfront payment Deferred Tax Liabilities Noncurrent Deferred tax liability Depreciation Depletion And Amortization Depreciation and amortization Disclosure Of Compensation Related Costs Sharebased Payments [Abstract] Disclosure of Compensation Related Costs, Share-based Payments [Abstract] Disclosure Of Compensation Related Costs Share Based Payments [Text Block] Stock-based Compensation Document and Entity Information [Abstract] Document And Entity Information [Abstract] Document And Entity Information [Abstract] Document Fiscal Period Focus Document Fiscal Period Focus Document Fiscal Year Focus Document Fiscal Year Focus Document Information [Line Items] Document Information [Line Items] Document Period End Date Document Period End Date Document Type Document Type Earnings Per Share [Abstract] Earnings Per Share [Abstract] Earnings Per Share Basic And Diluted Basic and diluted net loss per common share Earnings Per Share [Text Block] Net Loss Per Share Effect Of Exchange Rate On Cash And Cash Equivalents Effect of exchange rate changes on cash Employee Related Liabilities Current Accrued compensation and related expenses Employee Service Share Based Compensation Nonvested Awards Total Compensation Cost Not Yet Recognized Unamortized compensation cost Employee Service Share Based Compensation Nonvested Awards Total Compensation Cost Not Yet Recognized Period For Recognition 1 Unamortized compensation cost, vesting period Employee Stock [Member] Employee Stock Purchase Plan Employee Stock Purchase Plan, Number Of Shares Available for Issuance Employee Stock Purchase Plan Number Of Shares Available For Issuance Shares available for future issuance Employee stock purchase plan offering period. Employee Stock Purchase Plan Offering Period Employee stock purchase plan offering period Entities [Table] Entities [Table] Entity Central Index Key Entity Central Index Key Entity Common Stock Shares Outstanding Entity Common Stock, Shares Outstanding Entity [Domain] Entity [Domain] Entity Filer Category Entity Filer Category Entity Registrant Name Entity Registrant Name Equity [Abstract] Equity [Abstract] Equity Component [Domain] Equity Component [Domain] Equity Issuance Per Share Amount Shares purchase & equity issuance, per share amount Equity Method Investment Ownership Percentage Investment in China joint venture, percentage Percentage of outstanding voting stock Equity Method Investments And Joint Ventures [Abstract] Equity Method Investments and Joint Ventures [Abstract] Equity Method Investments Disclosure [Text Block] Joint Venture Equity method investment third party percentage. Equity Method Investment Third Party Percentage Other parties investment in China joint venture, percentage Fair Value By Fair Value Hierarchy Level [Axis] Fair Value, Hierarchy [Axis] Fair Value Disclosures [Abstract] Fair Value Disclosures [Abstract] Fair Value Inputs Level 1 [Member] Fair Value Measurements Using Level 1 Fair Value Measurement Inputs Disclosure [Text Block] Fair Value Measurements Fair Value Measurements Fair Value Hierarchy [Domain] Fair Value Hierarchy [Domain] Fair Value Measurements [Line Items] Fair Value Measurements [Line Items] Fair Value Measurements [Line Items] Fair Value Measurements [Table] Fair Value Measurements [Table] Fair Value Measurements [Table] Gain Loss On Disposition Of Assets Gain on disposal of assets General And Administrative Expense General and administrative Genzyme [Member] Genzyme [Member] Genzyme Agreement Goodwill Goodwill Income Loss From Continuing Operations Before Income Taxes Minority Interest And Income Loss From Equity Method Investments Loss before income taxes Income Loss From Equity Method Investments Change in value of equity method investment Income Statement [Abstract] Income Statement [Abstract] Income Statement Location [Axis] Income Statement Location [Axis] Income Statement Location [Domain] Income Statement Location [Domain] Income Taxes Paid Income taxes paid Income Tax Expense Benefit Income taxes The net change during the reporting period in the aggregate amount of accounts payable, accrued expenses, income taxes payable , deferred rent, and other similar obligations and liabilities. Increase Decrease In Accounts Payable Accrued Expenses Income Taxes Payable And Deferred Rent Accounts payable, income tax payable, accrued expenses and deferred rent Increase Decrease In Employee Related Liabilities Accrued compensation and related expenses Increase Decrease In Operating Capital [Abstract] Changes in operating assets and liabilities: Increase Decrease In Prepaid Deferred Expense And Other Assets Prepaid expenses and other assets Increase Decrease In Receivables Receivables Carrying amount as of the balance sheet date, which is the fair value of the acquired in-process technology, adjusted for any amortization recognized after market feasibility has been achieved and for any impairment charges. In Process Research And Development In-process research and development Interest Expense Interest expense Investments In Affiliates Subsidiaries Associates And Joint Ventures Investment in joint venture Investor [Member] Investor Legal Entity [Axis] Legal Entity [Axis] Liabilities Total liabilities Liabilities And Stockholders Equity Total liabilities and stockholders' equity Liabilities And Stockholders Equity [Abstract] Liabilities and Stockholders' Equity Liabilities Current Total current liabilities Liabilities Current [Abstract] Current liabilities: License Costs Patent-related expenses Licenses Revenue License revenue Macquarie Capital Incorporated [Member] Macquarie Capital Incorporated [Member] MCUSA Maximum [Member] Maximum Minimum [Member] Minimum Net Cash Provided By Used In Financing Activities Continuing Operations Net cash provided by financing activities Net Cash Provided By Used In Financing Activities Continuing Operations [Abstract] Financing activities: Net Cash Provided By Used In Investing Activities Continuing Operations Net cash (used in) provided by investing activities Net Cash Provided By Used In Investing Activities Continuing Operations [Abstract] Investing activities: Net Cash Provided By Used In Operating Activities Continuing Operations Net cash provided by (used in) operating activities Net Cash Provided By Used In Operating Activities Continuing Operations [Abstract] Operating activities: Net Income Loss Net loss Net Income Loss Available To Common Stockholders Basic Net loss applicable to common stockholders Net loss applicable to common stockholders Operating Expense [Member] Total Operating Expense Operating Expenses Total operating expenses Operating Expenses [Abstract] Operating expenses: Operating Income Loss Operating loss Other Comprehensive Income Loss Foreign Currency Transaction And Translation Adjustment Net Of Tax Foreign currency translation adjustments Other Comprehensive Income Loss Net Of Tax Period Increase Decrease [Abstract] Other comprehensive loss, net of tax: Other Nonoperating Expense Other expense Other Nonoperating Income Other income Payments Of Stock Issuance Costs Cost related to private placement Payments To Acquire Interest In Subsidiaries And Affiliates Investment in China joint venture Payments To Acquire Productive Assets Payments to acquire intellectual property programs and other assets Payments To Acquire Property Plant And Equipment Acquisition of property and equipment Percentage of employee compensation for purchase of common stock under espp. Percentage Of Employee Compensation For Purchase Of Common Stock Under Espp Percentage of employee compensation for purchase of common stock under ESPP Preferred Stock Par Or Stated Value Per Share Preferred stock, par value Series B Convertible Preferred Stock par value Preferred Stock Shares Authorized Preferred stock, shares authorized Preferred Stock Shares Issued Preferred stock, shares issued Preferred Stock Shares Outstanding Preferred stock, shares outstanding Preferred Stock Value Preferred stock, $0.01 par value; 3,000,000 shares authorized at March 31, 2014 and December 31, 2013; 220,000 shares issued and outstanding at March 31, 2014 and December 31, 2013 Prepaid Expense And Other Assets Current Prepaid expenses and other current assets Private Placement [Member] Private Placement Proceeds From Issuance Of Common Stock Proceeds from issuance of common stock, net of issuance costs Stock purchase agreement, proceeds Proceeds From Issuance Of Common Stock Gross Proceeds From Issuance Of Common Stock Gross Stock purchase agreement, gross proceeds Proceeds From Issuance Of Common Stock Net Proceeds From Issuance Of Common Stock Net Stock purchase agreement, net proceeds Proceeds From Issuance Of Private Placement Aggregate purchase price for shares and warrants under private placements Proceeds from Issuance of Private Placement Net Proceeds From Issuance Of Private Placement Net Net Proceeds form issuance of shares and warrants in private placement Proceeds From Issuance Of Stock Proceeds From Issuance Of Stock Gross proceeds Proceeds From Issuance Or Sale Of Equity Proceeds from issuance of equity awards Proceeds From Sale Of Property Plant And Equipment Proceeds from sales of property and equipment Proceeds From Stock Options Exercised Gross proceed from stock options exercised Proceeds From Warrant Exercises Proceeds from warrant exercises Warrant, exercisable value Property Plant And Equipment Net Property and equipment, net Quarterly Financial Information Disclosure [Abstract] Quarterly Financial Information Disclosure [Abstract] Quarterly Financial Information [Line Items] Quarterly Financial Information [Line Items] Quarterly Financial Information [Line Items] Quarterly Financial Information [Table] Quarterly Financial Information [Table] Quarterly Financial Information [Table] Quarterly Financial Information [Text Block] Interim Financial Information Range [Axis] Range [Axis] Range [Member] Range [Domain] Receivables Net Current Receivable Related Party [Domain] Related Party [Domain] Related Party Transaction [Line Items] Related Party Transaction [Line Items] Related Party Transactions [Abstract] Related Party Transactions [Abstract] Related Party Transactions By Related Party [Axis] Related Party [Axis] Related Party Transactions Disclosure [Text Block] Related Party Transactions Research And Development Arrangement Contract To Perform For Others Compensation Earned Revenue relating to research and development services Research And Development Expense Research and development Research Development And Patents Expense Research Development And Patents Expense Research, development and patents Research Development and Patents Expense, [Policy Text Block] Research Development And Patents Expense Policy [Text Block] Research, Development and Patents Retained Earnings Accumulated Deficit Accumulated deficit Revenue Recognition Policy [Text Block] Revenue Recognition Policy Revenue Recognition [Text Block] Revenue Recognition [Text Block] Revenue Recognition Revenues Revenues Sale Duration For Common Stock Under Purchase Agreement Sale Duration For Common Stock Under Purchase Agreement Stock purchase agreement, term of agreement Sale Of Stock Description Of Transaction Stock Purchase Agreement, maximum amount of sale terms Sale Of Stock Name Of Transaction [Domain] Sale of Stock, Name of Transaction [Domain] Sales Commission Sales Commission Sales commission as a percentage of gross proceeds Scenario 1 [Member] Scenario One [Member] April 17, 2013 At Market Sales Agreement Scenario 3 [Member] Scenario Three [Member] The second at-the-market equity distribution agreement Scenario 2 [Member] Scenario Two [Member] October 16, 2013 At Market Sales Agreement Scenario Unspecified [Domain] Scenario, Unspecified [Domain] Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Table] Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table] Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Text Block] Securities Excluded from Diluted Net Loss Per Common Share Schedule Of Capitalization Equity [Table] Schedule of Capitalization, Equity [Table] Schedule Of Related Party Transactions By Related Party [Table] Schedule of Related Party Transactions, by Related Party [Table] Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table] Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table] Schedule Of Share Based Compensation Stock Options Activity Table [Text Block] Summary of Stock Option Activity and Related Information