101 - Document - Document and Entity Information link:calculationLink link:presentationLink link:definitionLink 103 - Statement - CONSOLIDATED BALANCE SHEETS link:calculationLink link:presentationLink link:definitionLink 104 - Statement - CONSOLIDATED BALANCE SHEETS (Parenthetical) link:calculationLink link:presentationLink link:definitionLink 105 - Statement - CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS link:calculationLink link:presentationLink link:definitionLink 106 - Statement - CONSOLIDATED STATEMENTS OF CASH FLOWS link:calculationLink link:presentationLink link:definitionLink 107 - Disclosure - Interim Financial Information link:calculationLink link:presentationLink link:definitionLink 108 - Disclosure - Joint Venture link:calculationLink link:presentationLink link:definitionLink 109 - Disclosure - Fair Value Measurements link:calculationLink link:presentationLink link:definitionLink 110 - Disclosure - Net Loss Per Share link:calculationLink link:presentationLink link:definitionLink 111 - Disclosure - Balance Sheet Details link:calculationLink link:presentationLink link:definitionLink 112 - Disclosure - Stock-Based Compensation link:calculationLink link:presentationLink link:definitionLink 113 - Disclosure - Income Taxes link:calculationLink link:presentationLink link:definitionLink 114 - Disclosure - Commitments and Contingencies link:calculationLink link:presentationLink link:definitionLink 115 - Disclosure - Stockholders' Equity link:calculationLink link:presentationLink link:definitionLink 116 - Disclosure - Subsequent Events link:calculationLink link:presentationLink link:definitionLink 117 - Disclosure - Interim Financial Information (Policies) link:calculationLink link:presentationLink link:definitionLink 118 - Disclosure - Fair Value Measurements (Tables) link:calculationLink link:presentationLink link:definitionLink 119 - Disclosure - Net Loss Per Share (Tables) link:calculationLink link:presentationLink link:definitionLink 120 - Disclosure - Balance Sheet Details (Tables) link:calculationLink link:presentationLink link:definitionLink 121 - Disclosure - Stock-Based Compensation (Tables) link:calculationLink link:presentationLink link:definitionLink 122 - Disclosure - Stockholders' Equity (Tables) link:calculationLink link:presentationLink link:definitionLink 123 - Disclosure - Interim Financial Information - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 124 - Disclosure - Joint Venture - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 125 - Disclosure - Fair Value Measurements on Recurring Basis (Detail) link:calculationLink link:presentationLink link:definitionLink 126 - Disclosure - Fair Value Measurements - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 127 - Disclosure - Securities Excluded from Diluted Net Loss Per Common Share (Detail) link:calculationLink link:presentationLink link:definitionLink 128 - Disclosure - Accrued Expenses (Detail) link:calculationLink link:presentationLink link:definitionLink 129 - Disclosure - Stock-Based Compensation - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 130 - Disclosure - Weighted-Average Assumptions for Stock Option (Detail) link:calculationLink link:presentationLink link:definitionLink 131 - Disclosure - Changes in Stock Options Outstanding (Detail) link:calculationLink link:presentationLink link:definitionLink 132 - Disclosure - Stockholders Equity - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 133 - Disclosure - Subsequent Events - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink