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  <xsd:element id="mnov_AnnualIncreaseInSharesReservedForIssuance" name="AnnualIncreaseInSharesReservedForIssuance" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="mnov_AnnualIncreaseInSharesReservedForIssuanceAsPercentageOfOutstandingSharesOfCommonStock" name="AnnualIncreaseInSharesReservedForIssuanceAsPercentageOfOutstandingSharesOfCommonStock" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
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  <xsd:element id="mnov_FairValueAssetsLiabilitiesOtherThanCashAndCashEquivalentsAndInvestments" name="FairValueAssetsLiabilitiesOtherThanCashAndCashEquivalentsAndInvestments" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="mnov_FairValueMeasurementAssetLiabilityTransfersBetweenLevels" name="FairValueMeasurementAssetLiabilityTransfersBetweenLevels" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="mnov_IncreaseDecreaseInAccountsPayableAccruedExpensesAndOtherCurrentLiabilities" name="IncreaseDecreaseInAccountsPayableAccruedExpensesAndOtherCurrentLiabilities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
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  <xsd:element id="mnov_InvestmentsPurchasedMaturityPeriod" name="InvestmentsPurchasedMaturityPeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
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  <xsd:element id="mnov_NetOperatingLossCarryforwardsToCarriedForwardIndefinitely" name="NetOperatingLossCarryforwardsToCarriedForwardIndefinitely" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
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  <xsd:element id="mnov_ProceedsFromIssuanceOfCommonStockExerciseOfCommonStockOptions" name="ProceedsFromIssuanceOfCommonStockExerciseOfCommonStockOptions" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
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  <xsd:element id="mnov_ResearchDevelopmentAndPatentsExpense" name="ResearchDevelopmentAndPatentsExpense" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
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  <xsd:element id="mnov_StockIssuedDuringPeriodValueUnderAtTheMarketEquityDistributionAndSalesAgreements" name="StockIssuedDuringPeriodValueUnderAtTheMarketEquityDistributionAndSalesAgreements" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
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</xsd:schema>
