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Development Milestone [Member] Development Milestone Cash and Cash Equivalents [Axis] Cash and Cash Equivalents Defined Contribution Plan, Employer Discretionary Contribution Amount Discretionary contributions to employee savings plan Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted Average Remaining Contractual Term Weighted average contractual life, options exercisable Common Stock, Shares, Outstanding Common stock, shares outstanding Common Stock, Shares, Outstanding, Beginning Balance Common Stock, Shares, Outstanding, Ending Balance Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Risk Free Interest Rate Risk-free interest rate Share-Based Payment Arrangement [Text Block] Stock-based Compensation Effective Income Tax Rate Reconciliation, Permanent Differences Effective Income Tax Rate Reconciliation Permanent Differences Permanent differences Lessee, Operating Lease, Discount Rate Weighted-average discount rate Income Statement Location [Domain] Income Statement Location Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Grants in Period, Weighted Average Exercise Price Weighted Average Exercise Price, Granted License Agreement Terms [Member] Licensing Agreements Document Type Document Type Net cash provided by (used in) investing activities Net Cash Provided by (Used in) Investing Activities 2004 Plan, 2013 Plan and 2023 Plan Share-Based Payment Arrangement [Member] Counterparty Name [Domain] Counterparty Name Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested, Weighted Average Grant Date Fair Value Weighted Average Grant-Date Fair Value, Vested Deferred Tax Liabilities, Deferred Expense, Capitalized Research and Development Costs In-process research and development Revenue Recognition, Milestone Method [Line Items] Revenue Recognition Milestone Method [Line Items] Net Cash Provided by (Used in) Financing Activities Net cash provided by financing activities Entity Filer Category Entity Filer Category Deferred Tax Assets, Tax Credit Carryforwards, Research Research tax credits Schedule of Stockholders Equity [Table Text Block] Common Stock Reserved for Future Issuance Deferred tax assets research and experimentation capitalization. Deferred Tax Assets Research and Experimentation Capitalization Research and experimentation capitalization Other Comprehensive Income (Loss), Foreign Currency Transaction and Translation Adjustment, Net of Tax Foreign currency translation adjustments Foreign currency translation adjustments Other Comprehensive Income (Loss), Foreign Currency Transaction and Translation Adjustment, Net of Tax, Total Schedule of Income before Income Tax, Domestic and Foreign [Table Text Block] Reconciliation of Loss before Income Taxes for Domestic and Foreign Locations Short-Term Investments, Total Short-Term Investments Investments Mutual Funds Mutual Funds [Member] Mutual Funds Liabilities Total liabilities Equity, Attributable to Parent Balance Balance Total stockholders’ equity At market issuance sales agreement. At Market Issuance Sales Agreement [Member] At-the-market issuance sales agreement ATM Agreement Documents Incorporated by Reference [Text Block] Documents Incorporated by Reference Net loss Net loss Cash and Cash Equivalents [Domain] Cash and Cash Equivalents Effective Income Tax Rate Reconciliation, State and Local Income Taxes, Percent State income taxes, net of federal benefit Statement of Financial Position [Abstract] Weighted Average Number of Shares Outstanding, Diluted, Total Weighted Average Number of Shares Outstanding, Diluted Shares used to compute diluted net loss per common share Schedule of Effective Income Tax Rate Reconciliation [Table Text Block] Reconciliation of Federal Statutory Income Tax Rate to Effective Income Tax Rate Effective Income Tax Rate Reconciliation, Percent Provision for income taxes Deferred Federal Income Tax Expense (Benefit) Federal Operating Lease, Weighted Average Remaining Lease Term Weighted-average remaining lease term Use of Estimates, Policy [Policy Text Block] Use of Estimates Income Tax Disclosure [Text Block] Income Taxes Genzyme corporation. Genzyme Corporation [Member] Genzyme Corporation Deferred Tax Assets, Net [Abstract] Deferred tax assets: Effective income tax rate reconciliation expiration of attribute. Effective Income Tax Rate Reconciliation Expiration Of Attribute Expiration of attributes Revenue Recognition, Milestone Method [Table] Revenue Recognition Milestone Method [Table] Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price Weighted Average Exercise Price, Ending Balance Weighted Average Exercise Price, Beginning Balance Leasehold Improvements [Member] Leasehold Improvements Income Tax Authority [Axis] Income Tax Authority Fair Value Disclosures [Abstract] Current Income Tax Expense (Benefit) Current Income Tax Expense (Benefit), Total Total current income tax expense Furniture and Fixtures, Gross Furniture and equipment Fair Value Hierarchy and NAV [Axis] Fair Value Hierarchy and NAV Measurement Frequency [Domain] Payments to Acquire Property, Plant, and Equipment Acquisitions of property and equipment Payments to Acquire Property, Plant, and Equipment, Total Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period Number of vested shares Kissei Pharmaceutical Co., Ltd. Kissei Pharmaceutical Co Ltd [Member] Kissei Pharmaceutical Co., Ltd Issuance of common stock in a private placement transaction, net of issuance costs, shares Shares sold Issuance of common stock in a private transaction, net of issuance costs, shares Employee-related Liabilities, Current Accrued compensation Employee-related Liabilities, Current, Total Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Including Disposal Group and Discontinued Operations Cash and cash equivalents, end of year Cash and cash equivalents, beginning of year Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Including Disposal Group and Discontinued Operations, Total Income Tax Disclosure [Abstract] Operating Loss Carryforwards Net operating loss carryforwards