Accounting Policies [Abstract] Accounting Policies [Abstract] Accounts Payable Current Accounts payable Accrued Expenses [Line Items] Accrued Expenses [Line Items] Accrued Expenses [Line Items] Accrued Expenses [Table] Accrued Expenses [Table] Accrued Expenses [Table] Accrued Liabilities And Other Current Liabilities Accrued Liabilities And Other Current Liabilities Accrued expenses and other current liabilities Accrued Liabilities Current Accrued Liabilities, Current, Total Accrued Professional Fees Current Professional services fees Accrued Research and Development Expense, Current Accrued Research And Development Expense Current Research and development costs Accumulated Depreciation Depletion And Amortization Property Plant And Equipment Less accumulated depreciation and amortization Accumulated Other Comprehensive Income Loss Net Of Tax Accumulated other comprehensive loss Accumulated Other Comprehensive Income [Member] Accumulated other comprehensive loss Additional Paid In Capital Additional paid-in capital Additional Paid In Capital [Member] Additional paid-in capital Adjustments To Additional Paid In Capital Warrant Issued Fair value of warrant issued Adjustments To Reconcile Net Income Loss To Cash Provided By Used In Operating Activities [Abstract] Adjustments to reconcile net loss to net cash used in operating activities: Aggregate Intrinsic Value Of Stock Options Exercisable Aggregate Intrinsic Value Of Stock Options Exercisable Aggregate intrinsic value Amendment Flag Amendment Flag Antidilutive Securities Excluded From Computation Of Earnings Per Share Amount Total Antidilutive Securities Excluded From Computation Of Earnings Per Share By Antidilutive Securities [Axis] Antidilutive Securities [Axis] Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items] Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] Antidilutive Securities Name [Domain] Antidilutive Securities, Name [Domain] Aspire Capital Fund Llc [Member] Aspire Capital Fund Llc [Member] Aspire Capital Fund Llc Assets Total assets Assets [Abstract] Assets: Assets Current Total Current Assets Assets Current [Abstract] Current assets: Award Type [Axis] Award Type [Axis] Basis Of Presentation And Summary Of Significant Accounting Policies [Line Items] Basis Of Presentation And Summary Of Significant Accounting Policies [Line Items] Basis Of Presentation And Summary Of Significant Accounting Policies [Line Items] Basis Of Presentation And Summary Of Significant Accounting Policies [Table] Basis Of Presentation And Summary Of Significant Accounting Policies [Table] Basis Of Presentation And Summary Of Significant Accounting Policies [Table] California [Member] California [Member] California Capitalized Computer Software Gross Software Capital Loss Carryforward, Expiration Year Capital Loss Carryforward Expiration Year Capital loss carryovers, expiration year Cash And Cash Equivalents At Carrying Value Cash and cash equivalents, end of period Cash and cash equivalents, beginning of period Cash and cash equivalents Cash And Cash Equivalents Period Increase Decrease Net increase / (decrease) in cash and cash equivalents Cash And Cash Equivalents Policy [Text Block] Cash and Cash Equivalents Cash Equivalents Money Market Funds Cash Equivalents Money Market Funds Cash equivalents, including money market accounts Cash F D I C Insured Amount Cash insured amount Cash Payments Received Cash Payments Received Payment received Class Of Stock [Domain] Class of Stock [Domain] Class of Warrant or Right, Exercisable Class Of Warrant Or Right Exercisable Warrant, exercisable shares Class Of Warrant Or Right Exercise Price Of Warrants Or Rights Common share exercise price Class of Warrant or Right, Expiration Period Class Of Warrant Or Right Expiration Period Warrant, expiration period Class of Warrant or Right, Fair Value Class Of Warrant Or Right Fair Value Warrant, fair value Class Of Warrant Or Right Number Of Securities Called By Warrants Or Rights Warrant issued to purchase Common shares Class Of Warrant Or Rights Exercisable Period From Date Of Issuance Class Of Warrant Or Rights Exercisable Period From Date Of Issuance Warrant, exercisable period Commercialization Milestone [Member] Commercialization Milestone [Member] Commercialization Milestone Commitments And Contingencies Disclosure [Abstract] Commitments and Contingencies Disclosure [Abstract] Commitments And Contingencies Disclosure [Text Block] Commitments and Contingencies Common Stock Capital Shares Reserved For Future Issuance Common Stock reserved for future issuance Common stock fair market value percentage. Common Stock Fair Market Value Percentage Common stock fair market value, percentage Common Stock Maximum Sale Amount Under Purchase Agreement Common Stock Maximum Sale Amount Under Purchase Agreement Stock Purchase Agreement, maximum amount of sale Common Stock [Member] Common Stock Common Stock Par Or Stated Value Per Share Common stock, par value Common Stock Shares Authorized Common stock, shares authorized Common Stock Shares Issued Common stock, shares issued Common Stock Shares Outstanding Common stock, shares outstanding Common Stock Shares Subscriptions Stock purchase agreement, aggregate amount of common stock agreed to be purchased Common Stock Value Common stock, $0.001 par value; 100,000,000 shares authorized at December 31, 2013 and 2012; 22,495,443 and 17,407,311 shares issued at December 31, 2013 and 2012, respectively, and 22,495,443 and 17,403,125 shares outstanding at December 31, 2013 and 2012, respectively Compensation And Retirement Disclosure [Abstract] Compensation and Retirement Disclosure [Abstract] Components Of Earnings Loss Before Income Taxes [Line Items] Components Of Earnings Loss Before Income Taxes [Line Items] Components Of Earnings Loss Before Income Taxes [Line Items] Components Of Earnings Loss Before Income Taxes [Table] Components Of Earnings Loss Before Income Taxes [Table] Components Of Earnings Loss Before Income Taxes [Table] Components Of Income Tax Expense Benefit [Line Items] Components Of Income Tax Expense Benefit [Line Items] Components Of Income Tax Expense Benefit [Line Items] Components Of Income Tax Expense Benefit [Table] Components Of Income Tax Expense Benefit [Table] Components Of Income Tax Expense Benefit [Table] Comprehensive Income Net Of Tax Comprehensive loss Concentration Risk Credit Risk Concentrations and Credit Risk Consolidation Policy [Text Block] Principles of Consolidation Convertible Preferred Stock [Member] Convertible preferred stock, as converted Convertible Preferred Stock Shares Issued Upon Conversion Series B Preferred Stock, Shares Issued upon Conversion Convertible Preferred Stock Terms Of Conversion Series B Preferred stock conversion term Cumulative Stock Ownership Change Period Cumulative Stock Ownership Change Period Increase of ownership of certain stockholders or public groups in the stock, period Current Federal Tax Expense Benefit Federal Current Fiscal Year End Date Current Fiscal Year End Date Current Foreign Tax Expense Benefit Foreign Current Income Tax Expense Benefit Total current income tax expense Current State And Local Tax Expense Benefit State Decrease In Treasury Stock Decrease In Treasury Stock Decrease in treasury stock Deferred Compensation Arrangement With Individual Share Based Payments [Line Items] Deferred Compensation Arrangement with Individual, Share-based Payments [Line Items] Deferred Federal Income Tax Expense Benefit Federal Deferred Foreign Income Tax Expense Benefit Foreign Deferred Income Tax Expense Benefit Total deferred income tax expense Deferred Rent Credit Deferred rent Deferred Rent Non Current Deferred Rent Non Current Long-term deferred rent Deferred Revenue Deferred revenue related to research and development services Deferred Revenue Current Current deferred revenue Deferred Revenue Noncurrent Long-term deferred revenue Deferred Revenue Period Increase Decrease Amortization of Kissei upfront payment Deferred State And Local Income Tax Expense Benefit State Deferred Tax Assets, Capitalized Expenses Deferred Tax Assets Capitalized Expenses Capitalized licenses Deferred Tax Assets Gross Deferred tax assets Total deferred tax assets Deferred Tax Assets Liabilities Net Net deferred tax liability Deferred Tax Assets Net Net deferred tax assets Deferred Tax Assets Net [Abstract] Deferred tax assets: Deferred Tax Assets Operating Loss Carryforwards Net operating loss carryforwards Deferred Tax Assets Other Other deferred tax assets Other, net Deferred Tax Assets Tax Credit Carryforwards Research Research tax credits Deferred Tax Assets Tax Deferred Expense Compensation And Benefits Share Based Compensation Cost Deferred tax asset for stock based compensation adjustment Stock options Deferred Tax Assets Valuation Allowance Deferred tax assets valuation allowance adjustment Valuation allowance Deferred Tax Liabilities Total deferred tax liabilities Deferred Tax Liabilities [Abstract] Deferred tax liabilities Deferred Tax Liabilities Deferred Expense Capitalized Research And Development Costs In process R&D Deferred Tax Liabilities Noncurrent Deferred tax liability Defined Contribution Plan Disclosure [Line Items] Defined Contribution Plan Disclosure [Line Items] Defined Contribution Plan Disclosure [Line Items] Defined Contribution Plan Disclosure [Table] Defined Contribution Plan Disclosure [Table] Defined Contribution Plan Disclosure [Table] Defined Contribution Plan Employer Discretionary Contribution Amount Discretionary contributions to employee savings plan Depreciation Depreciation expense Depreciation Depletion And Amortization Depreciation and amortization Development Milestone [Member] Development Milestone [Member] Development Milestone Disclosure Of Compensation Related Costs Sharebased Payments [Abstract] Disclosure of Compensation Related Costs, Share-based Payments [Abstract] Disclosure Of Compensation Related Costs Share Based Payments [Text Block] Stock-based Compensation Document and Entity Information [Abstract] Document And Entity Information [Abstract] Document And Entity Information [Abstract] Document Fiscal Period Focus Document Fiscal Period Focus Document Fiscal Year Focus Document Fiscal Year Focus Document Information [Line Items] Document Information [Line Items] Document Period End Date Document Period End Date Document Type Document Type Earnings Per Share [Abstract] Earnings Per Share [Abstract] Earnings Per Share Basic Basic net income (loss) per common share Earnings Per Share Basic And Diluted Basic and diluted net loss per common share Earnings Per Share Diluted Diluted net income (loss) per common share Earnings Per Share Policy [Text Block] Net Loss Per Share Effective Income Tax Rate Continuing Operations Provision for income taxes Effective Income Tax Rate Reconciliation At Federal Statutory Income Tax Rate Federal statutory income tax rate Effective Income Tax Rate Reconciliation Change In Deferred Tax Assets Valuation Allowance Change in valuation allowance Effective Income Tax Rate Reconciliation Nondeductible Expense Share Based Compensation Cost Stock compensation Effective Income Tax Rate Reconciliation Other Adjustments Other Effective Income Tax Rate Reconciliation, Permanent Differences Effective Income Tax Rate Reconciliation Permanent Differences Permanent differences Effective Income Tax Rate Reconciliation State And Local Income Taxes State income taxes, net of federal benefit Effective Income Tax Rate Reconciliation Tax Exempt Income Tax credits Effect Of Exchange Rate On Cash And Cash Equivalents Effects of foreign exchange on cash Employee Related Liabilities Current Accrued compensation and other related expenses Employee Service Share Based Compensation Nonvested Awards Total Compensation Cost Not Yet Recognized Unamortized compensation cost Employee Service Share Based Compensation Nonvested Awards Total Compensation Cost Not Yet Recognized Period For Recognition 1 Unamortized compensation cost, vesting period Employee Stock [Member] Employee Stock Purchase Plan Employee Stock Option [Member] Stock Options Employee Stock Purchase Plan, Number Of Shares Available for Issuance Employee Stock Purchase Plan Number Of Shares Available For Issuance Shares available for future issuance Employee stock purchase plan offering period. Employee Stock Purchase Plan Offering Period Employee stock purchase plan offering period Entities [Table] Entities [Table] Entity Central Index Key Entity Central Index Key Entity Common Stock Shares Outstanding Entity Common Stock, Shares Outstanding Entity Current Reporting Status Entity Current Reporting Status Entity [Domain] Entity [Domain] Entity Filer Category Entity Filer Category Entity Public Float Entity Public Float Entity Registrant Name Entity Registrant Name Entity Voluntary Filers Entity Voluntary Filers Entity Well Known Seasoned Issuer Entity Well-known Seasoned Issuer Equity [Abstract] Equity [Abstract] Equity Component [Domain] Equity Component [Domain] Equity Issuance Per Share Amount Shares purchase & equity issuance, per share amount Equity Method Investment Ownership Percentage Investment in China joint venture, percentage Percentage of outstanding voting stock Equity Method Investments And Joint Ventures [Abstract] Equity Method Investments and Joint Ventures [Abstract] Equity Method Investments Disclosure [Text Block] Joint Venture Equity method investment third party percentage. Equity Method Investment Third Party Percentage Other parties investment in China joint venture, percentage Fair Value Disclosures [Abstract] Fair Value Disclosures [Abstract] Fair Value Measurement Inputs Disclosure [Text Block] Fair Value Measurements Fair Value Measurements [Line Items] Fair Value Measurements [Line Items] Fair Value Measurements [Line Items] Fair Value Measurements [Table] Fair Value Measurements [Table] Fair Value Measurements [Table] Fair Value Of Financial Instruments Policy Fair Value of Financial Instruments Federal and California [Member] Federal And California [Member] Federal and California Federal [Member] Federal [Member] Federal Financial Instrument [Axis] Financial Instrument [Axis] Furniture And Fixtures Gross Furniture and equipment Gain Loss On Disposition Of Assets (Gain) loss on disposal of assets General And Administrative Expense General and administrative Genzyme [Member] Genzyme [Member] Genzyme Agreement Goodwill Goodwill Goodwill And Intangible Assets Policy [Text Block] Goodwill and Purchased Intangibles Income Loss From Continuing Operations Before Income Taxes Domestic United States Income Loss From Continuing Operations Before Income Taxes Foreign Foreign Income Loss From Continuing Operations Before Income Taxes Minority Interest And Income Loss From Equity Method Investments Loss before income taxes Income Loss From Equity Method Investments Change in value of equity method investment Income Statement [Abstract] Income Statement [Abstract] Income Statement Location [Axis] Income Statement Location [Axis] Income Statement Location [Domain] Income Statement Location [Domain] Income Tax Authority [Axis] Income Tax Authority [Axis] Income Tax Authority [Domain] Income Tax Authority [Domain] Income Tax Disclosure [Abstract] Income Tax Disclosure [Abstract] Income Tax Disclosure [Text Block] Income Taxes Income Taxes Paid Income taxes paid Income Tax Expense Benefit Total income tax expense Income taxes Income Tax [Line Items] Income Tax [Line Items] Income Tax [Line Items] Income Tax Reconciliation Capital Loss Carry Over Income Tax Reconciliation Capital Loss Carry Over Capital loss carryovers Income Tax [Table] Income Tax [Table] Income Tax [Table] The net change during the reporting period in the aggregate amount of accounts payable, accrued expenses, income taxes payable , deferred rent, and other similar obligations and liabilities. Increase Decrease In Accounts Payable Accrued Expenses Income Taxes Payable And Deferred Rent Accounts payable, income tax payable, accrued expenses and deferred rent Increase Decrease In Employee Related Liabilities Accrued compensation and related expenses Increase Decrease In Operating Capital [Abstract] Changes in assets and liabilities: Increase Decrease In Prepaid Deferred Expense And Other Assets Prepaid expenses and other assets Increase Decrease In Receivables Receivables Increase in Accumulated Deficit Increase In Accumulated Deficit Increase in accumulated deficit Increase In Ownership Percentage Increase In Ownership Percentage Increase of ownership of certain stockholders or public groups in the stock, percentage Carrying amount as of the balance sheet date, which is the fair value of the acquired in-process technology, adjusted for any amortization recognized after market feasibility has been achieved and for any impairment charges. In Process Research And Development In-process research and development Investments In Affiliates Subsidiaries Associates And Joint Ventures Investment in joint venture Investor [Member] Investor Kissei Pharmaceutical Company Limited [Member] Kissei Pharmaceutical Company Limited [Member] Kissei Pharmaceutical Company Limited [Member] Lease Expiration, Month and Year Lease Expiration Month And Year Operating lease expiration period Leasehold Improvements Gross Leasehold improvements Legal Entity [Axis] Legal Entity [Axis] Lessee Leasing Arrangements Operating Leases Term Of Contract Operating lease, initial terms Liabilities Total liabilities Liabilities And Stockholders Equity Total liabilities and stockholders' equity Liabilities And Stockholders Equity [Abstract] Liabilities and Stockholders' Equity Liabilities Current Total current liabilities Liabilities Current [Abstract] Current liabilities: License Costs Patent-related expenses Licenses Revenue License revenue Licensing Agreements [Member] Licensing Agreements Loss Contingencies [Line Items] Loss Contingencies [Line Items] Loss Contingencies [Table] Loss Contingencies [Table] Macquarie Capital Incorporated [Member] Macquarie Capital Incorporated [Member] MCUSA Maximum [Member] Maximum Minimum [Member] Minimum Net Cash Provided By Used In Financing Activities Net cash provided by financing activities Net Cash Provided By Used In Financing Activities [Abstract] Financing activities: Net Cash Provided By Used In Investing Activities Net cash used in investing activities Net Cash Provided By Used In Investing Activities [Abstract] Investing activities: Net Cash Provided By Used In Operating Activities Net cash used in operating activities Net Cash Provided By Used In Operating Activities [Abstract] Operating activities: Net Income Loss Net income (loss) Net loss Net Income Loss Available To Common Stockholders Basic Net income (loss) applicable to common stockholders Net loss applicable to common shareholders Net loss applicable to common stockholders New Accounting Pronouncements Policy Policy [Text Block] Recent Accounting Pronouncements Operating Expenses Total operating expenses Total operating expenses Operating Expenses [Abstract] Operating expenses: Operating Income Loss Operating loss Operating Leased Assets [Line Items] Operating Leased Assets [Line Items] Operating Leases Future Minimum Payments Due Total minimum payments Operating Leases Future Minimum Payments Due Current 2014 Operating Leases Future Minimum Payments Due In Four Years 2017 Operating Leases Future Minimum Payments Due In Three Years 2016 Operating Leases Future Minimum Payments Due In Two Years 2015 Operating Leases Of Lessee Disclosure [Text Block] Future Minimum Payments Operating Leases Rent Expense Minimum Rentals Rent expense Operating Loss Carryforwards Net operating loss carry-forwards Operating Loss Carryforwards, Expiration Year Operating Loss Carryforwards Expiration Year Net operating loss carry forward, expiration year Option Indexed To Issuers Equity Type [Axis] Option Indexed to Issuer's Equity, Type [Axis] Option Indexed To Issuers Equity Type [Domain] Option Indexed to Issuer's Equity, Type [Domain] Organization Consolidation And Presentation Of Financial Statements [Abstract] Organization, Consolidation and Presentation of Financial Statements [Abstract] Organization Consolidation Basis Of Presentation Business Description And Accounting Policies [Text Block] Organization and Summary of Significant Accounting Policies Other Accrued Liabilities Current Other Other Asset Amortization Period Other Asset Amortization Period Warrant, amortization period Other Commitment Future potential milestone payments Other Comprehensive Income Loss Foreign Currency Transaction And Translation Adjustment Net Of Tax Foreign currency translation adjustments Other Comprehensive Income Loss Net Of Tax Period Increase Decrease [Abstract] Other comprehensive loss, net of tax: Other Nonoperating Expense Other expense Other Nonoperating Income Other income Payables And Accruals [Abstract] Payables and Accruals [Abstract] Payments Of Stock Issuance Costs Cost related to private placement Payments To Acquire Interest In Joint Venture Investment in China Joint Venture Payments To Acquire Interest In Subsidiaries And Affiliates Investment in China joint venture Payments To Acquire Productive Assets Payments to acquire intellectual property programs and other assets Payments To Acquire Property Plant And Equipment Acquisitions of property and equipment Pension And Other Postretirement Benefits Disclosure [Text Block] Employee Savings Plan Percentage of employee compensation for purchase of common stock under espp. Percentage Of Employee Compensation For Purchase Of Common Stock Under Espp Percentage of employee compensation for purchase of common stock under ESPP Postemployment Benefits [Abstract] Postemployment Benefits [Abstract] Preferred Stock [Member] Preferred stock Preferred Stock Par Or Stated Value Per Share Preferred stock, par value Series B Convertible Preferred Stock par value Preferred Stock Shares Authorized Preferred stock, shares authorized Preferred Stock Shares Issued Preferred stock, shares issued Preferred Stock Shares Outstanding Preferred stock, shares outstanding Preferred Stock Value Preferred stock, $0.01 par value; 3,000,000 shares authorized at December 31, 2013 and 2012; 220,000 shares issued and outstanding at December 31, 2013 and 2012 Prepaid Expense And Other Assets Current Prepaid expense and other current assets Private Placement [Member] Private Placement Proceeds From Issuance Of Common Stock Stock purchase agreement, proceeds Proceeds From Issuance Of Common Stock Gross Proceeds From Issuance Of Common Stock Gross Common Stock purchase agreement, gross proceeds from sale Proceeds From Issuance Of Common Stock Net Proceeds From Issuance Of Common Stock Net Common Stock purchase agreement, net proceeds from sale Proceeds From Issuance Of Private Placement Aggregate purchase price for shares and warrants under private placements Proceeds from Issuance of Private Placement Net Proceeds From Issuance Of Private Placement Net Net Proceeds form issuance of shares and warrants in private placement Proceeds From Issuance Of Stock Proceeds From Issuance Of Stock Gross proceeds Proceeds From Issuance Or Sale Of Equity Proceeds from issuance of common stock and warrants, net of issuance costs Proceeds From Sale Of Property Plant And Equipment Proceeds from sales of property and equipment Proceeds From Stock Options Exercised Proceed from stock options exercised Proceeds Or Payments For Issuance Or Repurchase Of Common Stock Net Proceeds Or Payments For Issuance Or Repurchase Of Common Stock Net Net proceeds from issuance of Treasury Stock under ESPP Product Development [Member] Product Development [Member] Product Development Property Plant And Equipment [Abstract] Property, Plant and Equipment [Abstract] Property, Plant, and Equipment Disclosure [Line Items] Property Plant And Equipment Disclosure [Line Items] Property, Plant, and Equipment Disclosure [Line Items] Property, Plant, and Equipment Disclosure [Table] Property Plant And Equipment Disclosure [Table] Property, Plant, and Equipment Disclosure [Table] Property Plant And Equipment Gross Property, Plant and Equipment, Gross, Total Property Plant And Equipment Net Property and equipment, net Property and equipment, net Property Plant And Equipment [Text Block] Property and Equipment Net Quarterly Financial Data [Line Items] Quarterly Financial Data [Line Items] Quarterly Financial Data [Line Items] Quarterly Financial Information Disclosure [Abstract] Quarterly Financial Information Disclosure [Abstract] Quarterly Financial Information [Text Block] Quarterly Financial Data Range [Axis] Range [Axis] Range [Member] Range [Domain] Receivables Net Current Receivable Reconciliation of Effective Income Tax Rate [Table] Reconciliation Of Effective Income Tax Rate [Table] Reconciliation of Effective Income Tax Rate [Table] Related Party [Domain] Related Party [Domain] Related Party Transaction [Axis] Related Party Transaction [Axis] Related Party Transaction [Domain] Related Party Transaction [Domain] Related Party Transaction [Line Items] Related Party Transaction [Line Items] Related Party Transactions [Abstract] Related Party Transactions [Abstract] Related Party Transactions By Related Party [Axis] Related Party [Axis] Related Party Transactions Disclosure [Text Block] Related Party Transactions Research And Development Arrangement Contract To Perform For Others By Type [Axis] Research and Development Arrangement, Contract to Perform for Others, Type [Axis] Research And Development Arrangement Contract To Perform For Others Compensation Earned Revenue relating to research and development services Research And Development Arrangement Contract To Perform For Others Type [Domain] Research and Development Arrangement, Contract to Perform for Others, Type [Domain] Research and Development Credits, Expiration Year Research And Development Credits Expiration Year Research and Development Credits, expiration period Research And Development Expense Research and development expense Research and development Research And Development Expense [Member] Research and development costs Research Development And Patents Expense Research Development And Patents Expense Research, development and patents Research Development and Patents Expense, [Policy Text Block] Research Development And Patents Expense Policy [Text Block] Research, Development and Patents Restatement Adjustment [Member] Restatement Adjustment Retained Earnings Accumulated Deficit Accumulated deficit Retained Earnings [Member] Accumulated deficit Revenue Recognition Milestone Method Revenue Recognized Milestone revenue Revenue Recognition Policy [Text Block] Revenue Recognition Policy Revenue Recognition [Text Block] Revenue Recognition [Text Block] Revenue Recognition Revenues Revenues Revenues [Abstract] Revenues: Sale Duration For Common Stock Under Purchase Agreement Sale Duration For Common Stock Under Purchase Agreement Stock purchase agreement, term of agreement Sale Of Stock Description Of Transaction Stock Purchase Agreement, maximum amount of sale terms Sale Of Stock Name Of Transaction [Domain] Sale of Stock, Name of Transaction [Domain] Sales Commission Sales Commission Sales commission as a percentage of gross proceeds Sales Revenue Services Net Research and development service revenue Scenario 4 [Member] Scenario Four [Member] Scenario 4 Scenario 1 [Member] Scenario One [Member] April 17, 2013 At Market Sales Agreement Scenario 3 [Member] Scenario Three [Member] Scenario 3 Scenario 2 [Member] Scenario Two [Member] October 16, 2013 At Market Sales Agreement Scenario Unspecified [Domain] Scenario, Unspecified [Domain] Schedule Of Accrued Liabilities Table [Text Block] Accrued Expenses Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Table] Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table] Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Text Block] Securities Excluded from Diluted Net Loss per Common Share Schedule Of Capitalization Equity [Table] Schedule of Capitalization, Equity [Table] Schedule Of Common Stock Reserved For Future Issuance Table [Text Block] Schedule Of Common Stock Reserved For Future Issuance Table [Text Block] Common Stock Reserved for Future Issuance Schedule Of Components Of Income Tax Expense Benefit Table [Text Block] Reconciliation of Income Tax Expense Schedule Of Deferred Compensation Arrangement With Individual Share Based Payments [Table] Schedule of Deferred Compensation Arrangement with Individual, Share-based Payments [Table] Schedule of Deferred Tax Assets and Liabilities [Line Items] Schedule Of Deferred Tax Assets And Liabilities [Line Items] Schedule of Deferred Tax Assets and Liabilities [Line Items] Schedule of Deferred Tax Assets and Liabilities [Table] Schedule Of Deferred Tax Assets And Liabilities [Table] Schedule of Deferred Tax Assets and Liabilities [Table] Schedule Of Deferred Tax Assets And Liabilities Table [Text Block] Components of Deferred IncomeTaxes Schedule Of Effective Income Tax Rate Reconciliation Table [Text Block] Reconciliation of Federal Statutory Income Tax Rate to Effective Income Tax Rate Schedule of Effective Tax Rate Reconciliation [Line Items] Schedule Of Effective Tax Rate Reconciliation [Line Items] Schedule of Effective Tax Rate Reconciliation [Line Items] Schedule Of Income Before Income Tax Domestic And Foreign Table [Text Block] Reconciliation of Income (Loss) before Income Taxes for Domestic and Foreign Locations Schedule Of Operating Leased Assets [Table] Schedule of Operating Leased Assets [Table] Schedule Of Quarterly Financial Data [Table] Schedule Of Quarterly Financial Data [Table] Schedule Of Quarterly Financial Data [Table] Schedule Of Quarterly Financial Information Table [Text Block] Summarized Quarterly Data Schedule Of Related Party Transactions By Related Party [Table] Schedule of Related Party Transactions, by Related Party [Table] Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table] Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table] Schedule Of Share Based Compensation Stock Options Activity Table [Text Block] Summary of Stock Option Activity and Related Information Schedule Of Share Based Payment Award Employee Stock Purchase Plan Valuation Assumptions Table [Text Block] Weighted-Average Assumptions for Stock Option Securities Purchase Agreement [Member] Securities Purchase Agreement [Member] Purchase Agreement Segment Reporting Policy Policy [Text Block] Segment Reporting Selling General And Administrative Expenses [Member] General and administrative expenses Series B Preferred Stock [Member] Series B Preferred Stock Share Based Compensation Non-cash stock-based compensation Stock-based compensation expense Share Based Compensation Arrangement By Share Based Payment Award Award Vesting Period 1 Stock option, vesting period Sharebased Compensation Arrangement By Sharebased Payment Award Expiration Period Options granted expiration term Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions And Methodology [Abstract] Weighted-average assumptions for stock options and ESPP Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Expected Dividend Rate Dividend yield Sharebased Compensation Arrangement By Sharebased Payment Award Fair Value Assumptions Expected Term 1 Expected option term (in years) Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Expected Volatility Rate Expected volatility of common stock Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Risk Free Interest Rate Risk-free interest rate Share Based Compensation Arrangement By Share Based Payment Award [Line Items] Share-based Compensation Arrangement by Share-based Payment Award [Line Items] Share Based Compensation Arrangement By Share Based Payment Award Number Of Shares Available For Grant Stock option available for future grant Share Based Compensation Arrangement By Share Based Payment Award Options Additional Disclosures [Abstract] Weighted Average Contractual Life Share-based Compensation Arrangement by Share-based Payment Award, Options, Aggregate Intrinsic Value [Abstract] Share Based Compensation Arrangement By Share Based Payment Award Options Aggregate Intrinsic Value [Abstract] Aggregate Intrinsic Value Sharebased Compensation Arrangement By Sharebased Payment Award Options Exercisable Intrinsic Value 1 Aggregate Intrinsic Value, Exercisable at December 31, 2013 Share Based Compensation Arrangement By Share Based Payment Award Options Exercisable Number Stock Options, Exercisable at December 31, 2013 Share Based Compensation Arrangement By Share Based Payment Award Options Exercisable Weighted Average Exercise Price Weighted Average Exercise Price, Exercisable at December 31, 2013 Sharebased Compensation Arrangement By Sharebased Payment Award Options Exercisable Weighted Average Remaining Contractual Term 1 Weighted Average Contractual Life, Exercisable at December 31, 2013 Share Based Compensation Arrangement By Share Based Payment Award Options Forfeitures And Expirations In Period Stock Options, Cancelled Share Based Compensation Arrangement By Share Based Payment Award Options Forfeitures And Expirations In Period Weighted Average Exercise Price Weighted Average Exercise Price, Cancelled Share Based Compensation Arrangement By Share Based Payment Award Options Grants In Period Gross Common stock options, granted Stock Options, Granted Share Based Compensation Arrangement By Share Based Payment Award Options Grants In Period Weighted Average Grant Date Fair Value Weighted-average fair value, per option Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Intrinsic Value Aggregate Intrinsic Value, Ending balance Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Number Stock Options, Ending Balance Stock Options, Beginning Balance Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding [Roll Forward] Number of Option Shares Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Weighted Average Exercise Price Weighted Average Exercise Price, Ending Balance Weighted Average Exercise Price, Beginning Balance Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Weighted Average Exercise Price Rollforward Weighted Average Exercise Price Sharebased Compensation Arrangement By Sharebased Payment Award Options Outstanding Weighted Average Remaining Contractual Term 2 Weighted Average Contractual Life, Ending balance Share Based Compensation Arrangement By Share Based Payment Award Shares Issued In Period Shares issued under ESPP Share Based Compensation Arrangements By Share Based Payment Award Award Type And Plan Name [Domain] Equity Award [Domain] Share Based Compensation Arrangements By Share Based Payment Award Options Exercises In Period Weighted Average Exercise Price Weighted Average Exercise Price, Exercised Share Based Compensation Arrangements By Share Based Payment Award Options Grants In Period Weighted Average Exercise Price Weighted Average Exercise Price, Granted Share Based Compensation Option And Incentive Plans Policy Stock-Based Compensation Share purchase agreement. Share Purchase Agreement [Axis] Share Purchase Agreement [Axis] Share purchase agreement. Share Purchase Agreement [Domain] Share Purchase Agreement [Domain] Share purchase agreement. Share Purchase Agreement [Member] Kissei Stock Purchase Agreement Shares Outstanding Ending Balance (in shares) Beginning Balance (in shares) Statement Class Of Stock [Axis] Class of Stock [Axis] Statement Equity Components [Axis] Equity Components [Axis] Statement [Line Items] Statement [Line Items] Statement Of Cash Flows [Abstract] Statement of Cash Flows [Abstract] Statement Of Financial Position [Abstract] Statement of Financial Position [Abstract] Statement Of Stockholders Equity [Abstract] Statement of Stockholders' Equity [Abstract] Statement Scenario [Axis] Scenario [Axis] Statement [Table] Statement [Table] Stock Compensation Plan [Member] 2000 Plan, 2004 Plan and 2013 Plan Stockholders Equity Ending Balance Beginning Balance Total stockholders' equity Stockholders Equity [Abstract] Stockholders' equity: Stockholders Equity Note Disclosure [Text Block] Stockholders' Equity Stock Issuance Limit Under Employee Stock Purchase Plan Description Stock Issuance Limit Under Employee Stock Purchase Plan Description Shares reserved, description Stock Issued During Period Shares Employee Stock Purchase Plans Issuance of shares under an employee stock purchase plan (in shares) Stock Issued During Period Shares Issued For Cash Issuance of common stock under a securities purchase agreement (in share) Common Stock purchase agreement, shares Common stock purchased, shares Stock Issued During Period Shares New Issues Issuance of common stock under a common stock purchase agreement (in shares) Warrant issued to purchase Common shares Stock Issued During Period Shares Stock Options Exercised Option exercises (in shares) Stock options exercised Stock Options, Exercised Stock Issued During Period Value Employee Stock Purchase Plan Issuance of shares under an employee stock purchase plan Stock Issued During Period Value Issued For Cash Issuance of common stock under securities purchase agreements Stock purchased, amount Stock Issued During Period Value New Issues Issuance of common stock under a common stock purchase agreement Stock Issued During Period Value Share Based Compensation Employee stock-based compensation Stock Issued During Period Value Stock Options Exercised Option exercises Stock Option [Member] Stock options Stock Plan Twenty Thirteen [Member] Stock Plan Twenty Thirteen [Member] Stock Plan 2013 Subsequent Event [Line Items] Subsequent Event [Line Items] Subsequent Event [Member] Subsequent Event Subsequent Events [Abstract] Subsequent Events [Abstract] Subsequent Events [Text Block] Subsequent Events Subsequent Event [Table] Subsequent Event [Table] Subsequent Event Type [Axis] Subsequent Event Type [Axis] Subsequent Event Type [Domain] Subsequent Event Type [Domain] Subsidiary Sale Of Stock [Axis] Subsidiary, Sale of Stock [Axis] Supplemental Balance Sheet Disclosures [Text Block] Balance Sheet Details Supplemental Cash Flow Information [Abstract] Supplemental disclosure of cash flow information: Tax Credit Carryforward Amount Research tax credit carry-forwards Text Block [Abstract] Text Block [Abstract] Trading Symbol Trading Symbol Transfers And Servicing Of Financial Instruments Types Of Financial Instruments [Domain] Financial Instruments [Domain] Treasury Stock [Member] Treasury Stock Treasury Stock Shares Treasury stock, shares Treasury Stock Value Treasury stock, at cost; zero shares at December 31, 2013 and 4,186 shares at December 31, 2012 Two Thousand Thirteen Plan [Member] Two Thousand Thirteen Plan [Member] 2013 Plan Uncategorized [Abstract] Uncategorized [Abstract] Uncategorized [Abstract] Use Of Estimates Use of Estimates Value of Consideration Received Value Of Consideration Received Additional consideration received for shares and warrants Warrant exercises. Warrant Exercises Warrant exercises Warrant exercises, shares. Warrant Exercises Shares Warrant exercises, shares Warrant [Member] Warrants Warrants expiration date. Warrants Expiration Date Warrant termination date Weighted Average Number Of Share Outstanding Basic And Diluted Shares used to compute basic and diluted net loss per common share Working Capital, Net Working Capital Net Working capital