Entity Central Index Key Document and entity information. Document And Entity Information [Abstract] Document Type Document Type Amendment Flag Amendment Flag Document Period End Date Document Period End Date Document Fiscal Year Focus Document Fiscal Year Focus Document Fiscal Period Focus Document Fiscal Period Focus Trading Symbol Trading Symbol Entity Registrant Name Entity Registrant Name Entity Central Index Key Current Fiscal Year End Date Current Fiscal Year End Date Entity Well-known Seasoned Issuer Entity Well Known Seasoned Issuer Entity Current Reporting Status Entity Current Reporting Status Entity Voluntary Filers Entity Voluntary Filers Entity Filer Category Entity Filer Category Entity Small Business Entity Small Business Entity Emerging Growth Company Entity Emerging Growth Company Entity Shell Company Entity Shell Company Entity Common Stock, Shares Outstanding Entity Common Stock Shares Outstanding Entity Public Float Entity Public Float Carrying amount as of the balance sheet date, which is the fair value of the acquired in-process technology, adjusted for any amortization recognized after market feasibility has been achieved and for any impairment charges. Statement Of Financial Position [Abstract] Assets: Assets [Abstract] Current assets: Assets Current [Abstract] Cash and cash equivalents Cash And Cash Equivalents At Carrying Value Prepaid expense and other current assets Prepaid Expense And Other Assets Current Total current assets Assets Current Goodwill Goodwill In-process research and development In Process Research And Development Investment in joint venture Investments In Affiliates Subsidiaries Associates And Joint Ventures Property and equipment, net Property Plant And Equipment Net Other long-term assets Other Assets Noncurrent Total assets Assets Liabilities and Stockholders’ Equity Liabilities And Stockholders Equity [Abstract] Current liabilities: Liabilities Current [Abstract] Accounts payable Accounts Payable Current Accrued liabilities Accrued Liabilities Current Total current liabilities Liabilities Current Long-term deferred rent and lease liability Deferred Rent Credit Noncurrent Deferred tax liability Deferred Tax Liabilities Noncurrent Long-term deferred revenue Deferred Revenue Noncurrent Total liabilities Liabilities Commitments and contingencies Commitments And Contingencies Stockholders’ equity: Stockholders Equity [Abstract] Common stock, $0.001 par value; 100,000,000 shares authorized at December 31, 2018 and December 31, 2017; 42,081,306 and 36,452,893 shares issued and outstanding at December 31, 2018 and December 31, 2017, respectively Common Stock Value Additional paid-in capital Additional Paid In Capital Common Stock Accumulated other comprehensive loss Accumulated Other Comprehensive Income Loss Net Of Tax Accumulated deficit Retained Earnings Accumulated Deficit Total stockholders’ equity Stockholders Equity Total liabilities and stockholders’ equity Liabilities And Stockholders Equity Common stock, par value Common Stock Par Or Stated Value Per Share Common stock, shares authorized Common Stock Shares Authorized Common stock, shares issued Common Stock Shares Issued Common stock, shares outstanding Common Stock Shares Outstanding Research, development and patents expense. Income Statement [Abstract] Operating expenses: Operating Expenses [Abstract] Research, development and patents Research Development And Patents Expense General and administrative General And Administrative Expense Total operating expenses Operating Expenses Operating loss Operating Income Loss Other expense, net Other Nonoperating Income Expense Interest income Interest Income Other Loss before income taxes Income Loss From Continuing Operations Before Income Taxes Extraordinary Items Noncontrolling Interest Income tax benefit (expense) Income Tax Expense Benefit Net loss applicable to common stockholders Net Income Loss Basic and diluted net loss per common share Earnings Per Share Basic And Diluted Shares used to compute basic and diluted net loss per share Weighted Average Number Of Share Outstanding Basic And Diluted Net loss applicable to common stockholders Other comprehensive income, net of tax: Other Comprehensive Income Loss Net Of Tax Period Increase Decrease [Abstract] Foreign currency translation adjustments Other Comprehensive Income Loss Foreign Currency Transaction And Translation Adjustment Net Of Tax Comprehensive loss Comprehensive Income Net Of Tax Stock issued during period value under at-the-market equity distribution and sales agreements. Stock issued during period shares under at-the-market equity distribution and sales agreements. Warrant exercises. Class of warrant or right, exercised in period. Statement Of Stockholders Equity [Abstract] Statement [Table] Statement [Table] Equity Components Statement Equity Components [Axis] Equity Component Equity Component [Domain] Preferred stock Preferred Stock [Member] Common stock Common Stock [Member] Additional paid-in capital Additional Paid In Capital [Member] Accumulated other comprehensive income (loss) Accumulated Other Comprehensive Income [Member] Accumulated deficit Retained Earnings [Member] Statement [Line Items] Statement [Line Items] Balance Balance, shares Shares Outstanding Share-based compensation Stock Issued During Period Value Share Based Compensation Issuance of shares under an employee stock purchase plan Stock Issued During Period Value Employee Stock Purchase Plan Issuance of shares under an employee stock purchase plan, shares Stock Issued During Period Shares Employee Stock Purchase Plans Issuance of common stock under public offering, net of offering costs Stock Issued During Period Value New Issues Issuance of common stock under public offering, net of offering costs, shares Stock Issued During Period Shares New Issues Issuance of common stock under at-the-market equity distribution and sales agreements, net of offering costs Stock Issued During Period Value Under At The Market Equity Distribution And Sales Agreements Issuance of common stock under at-the-market equity distribution and sales agreements, net of offering costs, shares Stock Issued During Period Shares Under At The Market Equity Distribution And Sales Agreements Conversion of preferred stock to common stock Stock Issued During Period Value Conversion Of Convertible Securities Conversion of preferred stock to common stock, shares Stock Issued During Period Shares Conversion Of Convertible Securities Issuance of common stock for option exercises Stock Issued During Period Value Stock Options Exercised Issuance of common stock for option exercises, shares Stock Issued During Period Shares Stock Options Exercised Exercise of warrants Warrant Exercises Exercise of warrants, shares Class Of Warrant Or Right Exercised In Period Net loss Balance Balance, shares Tax expense benefit from fluctuations in other comprehensive income. Amount of Increase (decrease) in receivables prepaid deferred expense and other assets. Amount of increase (decrease) in deferred tax liability, deferred revenue and other long term liabilities. Proceeds from issuance of common stock, exercise of common stock options and warrants, net of issuance costs. Statement Of Cash Flows [Abstract] Operating activities: Net Cash Provided By Used In Operating Activities [Abstract] Net loss Profit Loss Adjustments to reconcile net loss to net cash (used in) provided by operating activities: Adjustments To Reconcile Net Income Loss To Cash Provided By Used In Operating Activities [Abstract] Non-cash share-based compensation Share Based Compensation Depreciation and amortization Depreciation Depletion And Amortization Tax benefit from fluctuations in other comprehensive income Tax Expense Benefit From Fluctuations In Other Comprehensive Income Change in joint venture investment Income Loss From Equity Method Investments Changes in assets and liabilities: Increase Decrease In Operating Capital [Abstract] Receivables, prepaid expenses and other assets Increase Decrease In Receivables Prepaid Deferred Expense And Other Assets Accounts payable, accrued liabilities and other current liabilities Increase Decrease In Operating Liabilities Deferred tax liability, deferred revenue and other long-term liabilities Increase Decrease In Deferred Tax Liability Deferred Revenue And Other Long Term Liabilities Net cash used in operating activities Net Cash Provided By Used In Operating Activities Investing activities: Net Cash Provided By Used In Investing Activities [Abstract] Proceeds from dissolution of joint venture Proceeds From Divestiture Of Interest In Joint Venture Acquisitions of property and equipment Payments To Acquire Property Plant And Equipment Net cash provided by (used) in investing activities Net Cash Provided By Used In Investing Activities Financing activities: Net Cash Provided By Used In Financing Activities [Abstract] Proceeds from issuance of common stock, exercise of common stock options and warrants, net of issuance costs Proceeds From Issuance Of Common Stock Exercise Of Common Stock Options And Warrants Net Of Issuance Costs Proceeds from issuance of equity under ESPP Proceeds From Stock Plans Net cash provided by financing activities Net Cash Provided By Used In Financing Activities Effects of foreign exchange rates on cash Effect Of Exchange Rate On Cash And Cash Equivalents Net increase in cash and cash equivalents Cash And Cash Equivalents Period Increase Decrease Cash and cash equivalents, beginning of period Cash and cash equivalents, end of period Supplemental disclosure of cash flow information: Supplemental Cash Flow Information [Abstract] Income taxes paid Income Taxes Paid Accounting Policies [Abstract] Organization and Summary of Significant Accounting Policies Organization Consolidation Basis Of Presentation Business Description And Accounting Policies [Text Block] Revenue From Contract With Customer [Abstract] Revenue Recognition Revenue From Contract With Customer [Text Block] Fair Value Disclosures [Abstract] Fair Value Measurements Fair Value Measurement Inputs Disclosure [Text Block] Organization Consolidation And Presentation Of Financial Statements [Abstract] Balance Sheet Details Supplemental Balance Sheet Disclosures [Text Block] Commitments And Contingencies Disclosure [Abstract] Commitments and Contingencies Commitments And Contingencies Disclosure [Text Block] Equity Method Investments And Joint Ventures [Abstract] Joint Venture Equity Method Investments Disclosure [Text Block] Disclosure Of Compensation Related Costs Sharebased Payments [Abstract] Share-based Compensation Disclosure Of Compensation Related Costs Share Based Payments [Text Block] Equity [Abstract] Stockholders' Equity Stockholders Equity Note Disclosure [Text Block] Income Tax Disclosure [Abstract] Income Taxes Income Tax Disclosure [Text Block] Compensation And Retirement Disclosure [Abstract] Employee Savings Plan Pension And Other Postretirement Benefits Disclosure [Text Block] Quarterly Financial Information Disclosure [Abstract] Quarterly Financial Data Quarterly Financial Information [Text Block] Subsequent Events [Abstract] Subsequent Events Subsequent Events [Text Block] Principles of Consolidation Consolidation Policy [Text Block] Segment Reporting Segment Reporting Policy Policy [Text Block] Use of Estimates Use Of Estimates Cash and Cash Equivalents Cash And Cash Equivalents Policy [Text Block] Concentrations and Credit Risk Concentration Risk Credit Risk Fair Value of Financial Instruments Fair Value Of Financial Instruments Policy Goodwill and Purchased Intangibles Goodwill And Intangible Assets Policy [Text Block] Research development and patents expense. Research, Development and Patents Research Development And Patents Expense Policy [Text Block] Share-Based Compensation Share Based Compensation Option And Incentive Plans Policy Net Loss Per Share Earnings Per Share Policy [Text Block] Recent Accounting Pronouncements New Accounting Pronouncements Policy Policy [Text Block] Revenue Recognition Policy Revenue Recognition Policy [Text Block] Securities Excluded from Diluted Net Loss per Common Share Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Text Block] Property and Equipment Net Property Plant And Equipment [Text Block] Accrued Liabilities Schedule Of Accrued Liabilities Table [Text Block] Future Minimum Payments Operating Leases Of Lessee Disclosure [Text Block] Summary of Stock Option Activity and Related Information Schedule Of Share Based Compensation Stock Options Activity Table [Text Block] Weighted-Average Assumptions for Stock Option Schedule Of Share Based Payment Award Stock Options Valuation Assumptions Table [Text Block] Weighted-Average Assumptions for ESPP Schedule Of Share Based Payment Award Employee Stock Purchase Plan Valuation Assumptions Table [Text Block] Summary of Activity Under the ATM Agreements Schedule Of Sale Of Stock By Subsidiary Or Equity Method Investee Disclosure [Text Block] Common Stock Reserved for Future Issuance Schedule Of Stockholders Equity Table [Text Block] Reconciliation of Loss before Income Taxes for Domestic and Foreign Locations Schedule Of Income Before Income Tax Domestic And Foreign Table [Text Block] Reconciliation of Income Tax Benefit (Expense) Schedule Of Components Of Income Tax Expense Benefit Table [Text Block] Components of Deferred Income Taxes Schedule Of Deferred Tax Assets And Liabilities Table [Text Block] Reconciliation of Federal Statutory Income Tax Rate to Effective Income Tax Rate Schedule Of Effective Income Tax Rate Reconciliation Table [Text Block] Selected Quarterly Financial Information Schedule Of Quarterly Financial Information Table [Text Block] Working Capital, Net Basis of presentation and summary of significant accounting policies. Basis of presentation and summary of significant accounting policies. Basis Of Presentation And Summary Of Significant Accounting Policies [Table] Basis Of Presentation And Summary Of Significant Accounting Policies [Table] Range Range [Axis] Range Range [Member] Minimum Minimum [Member] Maximum Maximum [Member] Adjustments for New Accounting Pronouncements Adjustments For New Accounting Pronouncements [Axis] Type of Adoption Type Of Adoption [Member] ASU 2016-02 Accounting Standards Update201602 [Member] Subsequent Event Type Subsequent Event Type [Axis] Subsequent Event Type Subsequent Event Type [Domain] Subsequent Event Subsequent Event [Member] Basis Of Presentation And Summary Of Significant Accounting Policies [Line Items] Basis Of Presentation And Summary Of Significant Accounting Policies [Line Items] Working capital Working Capital Net Cash insured amount Cash F D I C Insured Amount Goodwill impairment Goodwill Impairment Loss Impairment of long-lived assets Impairment Of Long Lived Assets To Be Disposed Of Research and development Research And Development Expense Patents expense. Patent-related expenses Patents Expense Stock option, vesting period Share Based Compensation Arrangement By Share Based Payment Award Award Vesting Period1 Earnings Per Share [Abstract] Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Table] Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Table] Antidilutive Securities Antidilutive Securities Excluded From Computation Of Earnings Per Share By Antidilutive Securities [Axis] Antidilutive Securities, Name Antidilutive Securities Name [Domain] Stock option Employee Stock Option [Member] Warrants Warrant [Member] Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items] Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items] Total Antidilutive Securities Excluded From Computation Of Earnings Per Share Amount Number of properties identified in lease.